@ Sonja: Cartos need to be wet inside. If they go dry and you continue to use them it could develop a burnt taste that won't go away even after you fill them again. Keep them topped off or stop vaping them if they might be going dry to avoid this. I don't think the position of them makes much difference in a carto. In a clearo it is helpful to tip them when they get low on juice.
@ icrarussound and Sonja: Not all cartos are made equally either. Some may be much lower in resistance than is marked or just plain defective.