This is pretty old but I'll give my two cents. Nicotine releases a wide array of neurotransmitters in the brain, most of which have a tendency to wake one up. However serotonin is broken down into melatonin in the brain, so you may feel sleepy a while after the buzz has left.
Nicotine Makes You Sleepy?
in General Vaping Discussion
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This is pretty old but I'll give my two cents. Nicotine releases a wide array of neurotransmitters in the brain, most of which have a tendency to wake one up. However serotonin is broken down into melatonin in the brain, so you may feel sleepy a while after the buzz has left.